The mechanism of action of nicotine is an important research in the field of life science and public health. The team of Li Xiang, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, has been studying nicotine for a long time. Recently, Li Xiang’s team published an article entitled “Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity” online in Nature Communications, revealing the researchers’ latest findings on the mechanism of nicotine.

Li Xiang’s team found that chronic low-dose nicotine can improve energy metabolism and delay systemic aging by activating the NAD+ recovery pathway. This idea was confirmed in mouse experiments. The researchers conducted observations and cell tests on mice drinking low-dose nicotine water for a long time, and found that nicotine has a positive effect on neuroprotection, and can promote the interaction of two proteases in cells, reduce the level of aging factors, and enhance the activity of NAD+. Thereby improving the metabolic rate of aging tissues. In addition, the researchers also found that after nicotine was decomposed in the mouse liver, it could relieve the anxiety of the mice and improve their learning and memory functions.

This study by the Chinese team provides new targets and methods for expanding the application of nicotine and anti-aging, and once again confirms that nicotine is not all harmful. Adequate nicotine intake still has certain positive effects on the body. Nicotine is currently widely present in tobacco, and electronic cigarettes are a new form of nicotine intake.
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